Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

The discovery and implementation of antibiotics in the early twentieth century transformed
human health and wellbeing. Chemical synthesis enabled the development of the first …

Cyclic peptides have been attracting a lot of attention in recent decades, especially in the
area of drug discovery, as more and more naturally occurring cyclic peptides with diverse …

Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …

As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …

Over the years, alkaloids derived from indole dearomatization, such as indolenine and
indolines have been evolved as promising therapeutic agents due to their important …

The polymyxin and lipopeptide classes of antibiotics are membrane-targeting drugs of last
resort used to treat infections caused by multi-drug-resistant pathogens. Despite similar …

Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

Covering: 2012 to 2013. Previous review: Nat. Prod. Rep., 2013, 30, 694–752 This review
covers the literature on simple indole alkaloids and those with a nonrearranged …

Covering: up to 2014 In this review we investigate the use of complex ester fragment
couplings within natural product total synthesis campaigns. We first outline the different …