Small molecule metabolites: discovery of biomarkers and therapeutic targets
S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Y Chen, T Lu, U Pettersson-Kymmer, ID Stewart… - Nature …, 2023 - nature.com
Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
A cross-platform approach identifies genetic regulators of human metabolism and health
In cross-platform analyses of 174 metabolites, we identify 499 associations (P< 4.9× 10− 10)
characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and …
characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and …
Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
L Ottensmann, R Tabassum, SE Ruotsalainen… - Nature …, 2023 - nature.com
The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …
lipid-associated variants and understand the link between lipid species and cardiometabolic …
Genome–microbiome interplay provides insight into the determinants of the human blood metabolome
Variation in the blood metabolome is intimately related to human health. However, few
details are known about the interplay between genetics and the microbiome in explaining …
details are known about the interplay between genetics and the microbiome in explaining …
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
AA Brown, JJ Fernandez-Tajes, M Hong… - Nature …, 2023 - nature.com
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity …
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity …
The selection landscape and genetic legacy of ancient Eurasians
Abstract The Holocene (beginning around 12,000 years ago) encompassed some of the
most significant changes in human evolution, with far-reaching consequences for the …
most significant changes in human evolution, with far-reaching consequences for the …
Leptin alters energy intake and fat mass but not energy expenditure in lean subjects
P Chrysafi, N Perakakis, OM Farr, K Stefanakis… - Nature …, 2020 - nature.com
Based on studies in mice, leptin was expected to decrease body weight in obese
individuals. However, the majority of the obese are hyperleptinemic and do not respond to …
individuals. However, the majority of the obese are hyperleptinemic and do not respond to …