Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Systems biology in cardiovascular disease: a multiomics approach

A Joshi, M Rienks, K Theofilatos, M Mayr - Nature Reviews Cardiology, 2021 - nature.com
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

Y Chen, T Lu, U Pettersson-Kymmer, ID Stewart… - Nature …, 2023 - nature.com
Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …

Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases

N de Klein, EA Tsai, M Vochteloo, D Baird, Y Huang… - Nature …, 2023 - nature.com
Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …

A cross-platform approach identifies genetic regulators of human metabolism and health

LA Lotta, M Pietzner, ID Stewart, LBL Wittemans, C Li… - Nature …, 2021 - nature.com
In cross-platform analyses of 174 metabolites, we identify 499 associations (P< 4.9× 10− 10)
characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and …

Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

L Ottensmann, R Tabassum, SE Ruotsalainen… - Nature …, 2023 - nature.com
The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …

Genome–microbiome interplay provides insight into the determinants of the human blood metabolome

C Diener, CL Dai, T Wilmanski, P Baloni, B Smith… - Nature …, 2022 - nature.com
Variation in the blood metabolome is intimately related to human health. However, few
details are known about the interplay between genetics and the microbiome in explaining …

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

AA Brown, JJ Fernandez-Tajes, M Hong… - Nature …, 2023 - nature.com
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity …

The selection landscape and genetic legacy of ancient Eurasians

EK Irving-Pease, A Refoyo-Martínez, W Barrie… - Nature, 2024 - nature.com
Abstract The Holocene (beginning around 12,000 years ago) encompassed some of the
most significant changes in human evolution, with far-reaching consequences for the …

Leptin alters energy intake and fat mass but not energy expenditure in lean subjects

P Chrysafi, N Perakakis, OM Farr, K Stefanakis… - Nature …, 2020 - nature.com
Based on studies in mice, leptin was expected to decrease body weight in obese
individuals. However, the majority of the obese are hyperleptinemic and do not respond to …