RUNX transcription factors: orchestrators of development
ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
Xenograft models for normal and malignant stem cells
S Goyama, M Wunderlich… - Blood, The Journal of the …, 2015 - ashpublications.org
The model systems available for studying human hematopoiesis, malignant hematopoiesis,
and hematopoietic stem cell (HSC) function in vivo have improved dramatically over the last …
and hematopoietic stem cell (HSC) function in vivo have improved dramatically over the last …
Production of gene-corrected adult beta globin protein in human erythrocytes differentiated from patient iPSCs after genome editing of the sickle point mutation
Human induced pluripotent stem cells (iPSCs) and genome editing provide a precise way to
generate gene-corrected cells for disease modeling and cell therapies. Human iPSCs …
generate gene-corrected cells for disease modeling and cell therapies. Human iPSCs …
Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells
Recent reports have shown that somatic cells, under appropriate culture conditions, could
be directly reprogrammed to cardiac, hepatic, or neuronal phenotype by lineage-specific …
be directly reprogrammed to cardiac, hepatic, or neuronal phenotype by lineage-specific …
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
RBM15, an RNA binding protein, determines cell-fate specification of many tissues including
blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 …
blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 …
Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells
CD16a and CD16b are IgG Fc receptors expressed by human natural killer (NK) cells and
neutrophils, respectively. Both CD16 isoforms undergo a rapid down-regulation in …
neutrophils, respectively. Both CD16 isoforms undergo a rapid down-regulation in …
De novo generation of HSCs from somatic and pluripotent stem cell sources
Generating human hematopoietic stem cells (HSCs) from autologous tissues, when coupled
with genome editing technologies, is a promising approach for cellular transplantation …
with genome editing technologies, is a promising approach for cellular transplantation …
[PDF][PDF] Hematopoietic stem cell expansion and generation: the ways to make a breakthrough
B Park, KH Yoo, C Kim - Blood research, 2015 - synapse.koreamed.org
Hematopoietic stem cell transplantation (HSCT) is the first field where human stem cell
therapy was successful. Flooding interest on human stem cell therapy to cure previously …
therapy was successful. Flooding interest on human stem cell therapy to cure previously …
Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells
II Slukvin - Blood, The Journal of the American Society of …, 2013 - ashpublications.org
Significant advances in cellular reprogramming technologies and hematopoietic
differentiation from human pluripotent stem cells (hPSCs) have already enabled the routine …
differentiation from human pluripotent stem cells (hPSCs) have already enabled the routine …
The genetic and molecular pathogenesis of myelodysplastic syndromes
RM Shallis, R Ahmad, AM Zeidan - European journal of …, 2018 - Wiley Online Library
Myelodysplastic syndromes (MDS) comprise a diverse group of clonal and malignant
myeloid disorders characterized by ineffective hematopoiesis, resultant peripheral …
myeloid disorders characterized by ineffective hematopoiesis, resultant peripheral …