Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward. An Official American Thoracic Society Research Statement
Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short-and long-term outcomes. Although …
syndromes is a significant determinant of short-and long-term outcomes. Although …
CircRPN2 inhibits aerobic glycolysis and metastasis in hepatocellular carcinoma
J Li, ZQ Hu, SY Yu, L Mao, ZJ Zhou, PC Wang, Y Gong… - Cancer Research, 2022 - AACR
Although circular RNAs (circRNA) are known to modulate tumor initiation and progression,
their role in hepatocellular carcinoma (HCC) metastasis remains poorly understood. Here …
their role in hepatocellular carcinoma (HCC) metastasis remains poorly understood. Here …
The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure
The right ventricle (RV) is the major determinant of functional state and prognosis in
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF
D Bode, L Semmler, P Wakula, N Hegemann… - Cardiovascular …, 2021 - Springer
Background Sodium–glucose linked transporter type 2 (SGLT-2) inhibition has been shown
to reduce cardiovascular mortality in heart failure independently of glycemic control and …
to reduce cardiovascular mortality in heart failure independently of glycemic control and …
Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension
R Savai, HM Al-Tamari, D Sedding, B Kojonazarov… - Nature medicine, 2014 - nature.com
Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis
resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) …
resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) …
Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
X Wang, X Shen, Y Yan, H Li - Bioscience Reports, 2021 - portlandpress.com
Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate
decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …
decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …
Fatty acid metabolic defects and right ventricular lipotoxicity in human pulmonary arterial hypertension
Background—The mechanisms of right ventricular (RV) failure in pulmonary arterial
hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have …
hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have …
Right ventricular adaptation and failure in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is an obstructive pulmonary vasculopathy,
characterized by excess proliferation, apoptosis resistance, inflammation, fibrosis, and …
characterized by excess proliferation, apoptosis resistance, inflammation, fibrosis, and …
Epigenetic metabolic reprogramming of right ventricular fibroblasts in pulmonary arterial hypertension: a pyruvate dehydrogenase kinase-dependent shift in …
Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to
RV failure. While RV fibrosis reflects changes in the function of resident RV fibroblasts …
RV failure. While RV fibrosis reflects changes in the function of resident RV fibroblasts …