Understanding risk factors for substance use disorders (SUD) can facilitate medication
development for SUD treatment. While a rich literature exists discussing environmental …

The gut microbiome is thought to play a critical role in the onset and development of
psychiatric disorders, including depression and substance use disorder (SUD). To test the …

Introduction: Preclinical literature, frequently utilizing rats, suggests females display a more
rapid advancement of substance abuse and a greater risk of relapse following drug …

Lifetime and temporal co-occurrence of substance use disorders (SUDs) is common and
compared with individual SUDs is characterized by greater severity, additional psychiatric …

Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the
development and maintenance of addiction. Rodent studies suggest that this sensitivity is …

Impulsive behavior and impulsivity are heritable phenotypes that are strongly associated
with risk for substance use disorders. Identifying the neurogenetic mechanisms that …

Mouse models are an essential tool in different areas of research, including nutrition and
phytochemical research. Traditional inbred mouse models have allowed the discovery of …

Drug addiction is considered the pathological usurpation of normal learning and memory. G
protein-coupled estrogen receptor 1 (GPER1) plays an important role in normal learning and …

Cell-autonomous circadian clocks exist in nearly every organ and function to maintain
homeostasis through a complex series of transcriptional-translational feedback loops. The …

Azoxymethane (AOM) is a widely used carcinogen to study chemical-induced colorectal
carcinogenesis and is an agent for studying fulminant hepatic failure. The inter-strain …