Anthracyclines, such as doxorubicin and idarubicin, remain an important class of
chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a …

Since poly-ADP ribose was discovered over 40 years ago, there has been significant
progress in research into the biology of mono-and poly-ADP-ribosylation reactions. During …

Despite great advances in therapies observed during the last decades, heart failure (HF)
remained a major health problem in western countries. In order to further improve symptoms …

Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …

Chromatin regulation provides an important means for controlling cardiac gene expression
under different physiological and pathological conditions. Processes that direct the …

Poly (ADP-ribose) polymerase (PARP) inhibitors have recently been introduced in the
therapy of several types of cancers not responding to conventional treatments. However, de …

Chronic isoproterenol administration produces a rapid, highly reproducible rodent model of
cardiac hypertrophy. Yet, despite widespread use of this model, the effects of isoproterenol …

Signaling cascades provide integrative and interactive frameworks that allow the cell to
respond to signals from its environment and/or from within the cell itself. The dynamic …

Ethnopharmacological relevance Many studies have emphasized that flavonoids, found in
various fruits, vegetables, and seeds, as well as tea and red wine, have potential health …

Purpose The cytoprotective effect of poly (ADP-ribose) polymerase 1 (PARP1) inhibition is
well documented in various cell types subjected to oxidative stress. Previously, we have …