For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Peptides as a therapeutic modality attract much attention due to their synthetic accessibility,
high degree of specific binding, and the ability to target protein surfaces traditionally …

The BCL-2 family of proteins controls cell death primarily by direct binding interactions that
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …

Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Ruthenium-based olefin metathesis catalysts, known for their functional group tolerance and
broad applicability in organic synthesis and polymer science, continue to evolve as an …

A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

We report the discovery of sulanemadlin (ALRN-6924), the first cell-permeating, stabilized α-
helical peptide to enter clinical trials. ALRN-6924 is a “stapled peptide” that mimics the N …

Protein–protein interactions (PPIs) are of pivotal importance in the regulation of biological
systems and are consequently implicated in the development of disease states. Recent work …

In multicellular organisms the regulated cell death apoptosis is critically important for both
ontogeny and homeostasis. Mitochondria are indispensable for stress-induced apoptosis …

The clinical translation of cationic α-helical antimicrobial peptides (AMPs) has been
hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspecific …