A Novel Self‐Amplifying mRNA with Decreased Cytotoxicity and Enhanced Protein Expression by Macrodomain Mutations
Y Gong, D Yong, G Liu, J Xu, J Ding, W Jia - Advanced Science, 2024 - Wiley Online Library
The efficacy and safety of self‐amplifying mRNA (saRNA) have been demonstrated in
COVID‐19 vaccine applications. Unlike conventional non‐replicating mRNA (nrmRNA) …
COVID‐19 vaccine applications. Unlike conventional non‐replicating mRNA (nrmRNA) …
Translational Control of Alphavirus–Host Interactions: Implications in Viral Evolution, Tropism and Antiviral Response
I Ventoso, JJ Berlanga, R Toribio, I Díaz-López - Viruses, 2024 - mdpi.com
Alphaviruses can replicate in arthropods and in many vertebrate species including
humankind, but only in vertebrate cells do infections with these viruses result in a strong …
humankind, but only in vertebrate cells do infections with these viruses result in a strong …
Broad-spectrum immune suppression encoded in self-amplifying RNA enables non-cytotoxic, non-immunostimulatory, reversible transgene expression
Self-amplifying RNA (saRNA) has the potential to provide durable, non-integrative
transgene expression for transient gene therapy. However, its auto-replicative nature mimics …
transgene expression for transient gene therapy. However, its auto-replicative nature mimics …
Nanopore Direct RNA Sequencing and Proteomics Reveals Virus-Induced Changes in Human Cells
D Wang - 2024 - search.proquest.com
Influenza virus remains a pervasive global health threat due to its rapid mutation and
immune evasion capabilities, resulting in frequent epidemics and sporadic pandemics. This …
immune evasion capabilities, resulting in frequent epidemics and sporadic pandemics. This …
Construction of nervous necrosis virus (NNV) genome-based DNA replicon vectors for the delivery of foreign antigens
JI Yang, KH Kim - Journal of fish pathology, 2024 - koreascience.kr
The advantages of replicon vectors of RNA viruses include a high ability to stimulate innate
immunity and exponential amplification of target mRNA leading to high expression of foreign …
immunity and exponential amplification of target mRNA leading to high expression of foreign …
[HTML][HTML] 多様なエンジニアリング戦略によって広がる人工mRNA の可能性
大野博久， 齊藤博英 - Journal of Japanese Biochemical …, 2024 - seikagaku.jbsoc.or.jp
新型コロナウイルスワクチンの実用化により人工 mRNA が大きな注目を集めている.
設計が容易でゲノムに組み込まれる恐れがないなど, 多くの利点を持つ人工 mRNA は …
設計が容易でゲノムに組み込まれる恐れがないなど, 多くの利点を持つ人工 mRNA は …