Epigenetic regulation in neurodegenerative diseases
Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling,
and histone post-translational modifications, are involved in multiple aspects of neuronal …
and histone post-translational modifications, are involved in multiple aspects of neuronal …
Mitochondrial iron metabolism and neurodegenerative diseases
Iron is a key element for mitochondrial function and homeostasis, which is also crucial for
maintaining the neuronal system, but too much iron promotes oxidative stress. A large body …
maintaining the neuronal system, but too much iron promotes oxidative stress. A large body …
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia but has no effective
treatment. A comprehensive investigation of cell type-specific responses and cellular …
treatment. A comprehensive investigation of cell type-specific responses and cellular …
[HTML][HTML] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
Sex-specific transcriptional signatures in human depression
Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …
incidence, symptoms and treatment of MDD all point toward major sex differences, the …
Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease
Alzheimer's disease (AD) lacks protein biomarkers reflective of its diverse underlying
pathophysiology, hindering diagnostic and therapeutic advancements. Here, we used …
pathophysiology, hindering diagnostic and therapeutic advancements. Here, we used …
[HTML][HTML] A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer's disease
Here, we report proteomic analyses of 129 human cortical tissues to define changes
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …
The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease
Increased dietary intake of niacin has been correlated with reduced risk of Alzheimer's
disease (AD). Niacin serves as a high-affinity ligand for the receptor HCAR2 (GPR109A). In …
disease (AD). Niacin serves as a high-affinity ligand for the receptor HCAR2 (GPR109A). In …
DGCA: a comprehensive R package for differential gene correlation analysis
Background Dissecting the regulatory relationships between genes is a critical step towards
building accurate predictive models of biological systems. A powerful approach towards this …
building accurate predictive models of biological systems. A powerful approach towards this …
Prediction of Alzheimer's disease based on deep neural network by integrating gene expression and DNA methylation dataset
Motivation The molecular mechanism of Alzheimer's disease (AD) has not been clearly
revealed and there is no clinically reliable genetic risk factor. Therefore, diagnosis of AD has …
revealed and there is no clinically reliable genetic risk factor. Therefore, diagnosis of AD has …