Kristen rat sarcoma (KRAS) is one of the most common oncogenes in human cancers. As a
guanine nucleotide exchange factor, Son of Sevenless Homologue 1 (SOS1) represents a …

SOS1 is one of the major guanine nucleotide exchange factors that regulates the ability of
KRAS to cycle through its “on” and “off” states. Disrupting the SOS1: KRASG12C protein …

Cardiovascular diseases continue to challenge global health, demanding innovative
therapeutic solutions. This review delves into the transformative role of mesenchymal stem …

Generation of induced pluripotent stem cells (iPSCs) and their differentiation into
mesenchymal stem/stromal cells (iMSCs) have created exciting source of cells for …

Cardiovascular diseases, atherosclerosis, and strokes are the most common causes of
death in patients with Hutchinson-Gilford progeria syndrome (HGPS). The LMNA variant c …

It has been challenging to target mutant KRAS (mKRAS) in colorectal cancer (CRC) and
other malignancies. Recent efforts have focused on developing inhibitors blocking …

Non-coding RNAs, particularly small Cajal-body associated RNAs (scaRNAs), play a
significant role in spliceosomal RNA modifications. While their involvement in ischemic …

Aims Perform in-silico analysis of human SOS1 mutations to elucidate their pathogenic role
in Noonan syndrome (NS). Background NS is an autosomal dominant genetic disorder …

Congenital heart disease (CHD) represents a major class of birth defects worldwide and is
associated with cardiac malformations that often require surgical intervention immediately …

Background It has been challenging to develop agents directly targeting KRAS driver
mutations in colorectal cancer (CRC). Recent efforts have focused on developing inhibitors …