Four billion years of microbial terpenome evolution
Y Hoshino, L Villanueva - FEMS microbiology reviews, 2023 - academic.oup.com
Terpenoids, also known as isoprenoids, are the largest and most diverse class of organic
compounds in nature and are involved in many membrane-associated cellular processes …
compounds in nature and are involved in many membrane-associated cellular processes …
Chemo-enzymatic synthesis of natural products and their analogs
F Kaspar, A Schallmey - Current Opinion in Biotechnology, 2022 - Elsevier
Enzymes continue to gain recognition as valuable tools in synthetic chemistry as they
enable transformations, which elude conventional organochemical approaches. As such …
enable transformations, which elude conventional organochemical approaches. As such …
First trans-eunicellane terpene synthase in bacteria
Terpenoids are the largest family of natural products, but prokaryotes are vastly
underrepresented in this chemical space. However, genomics supports vast untapped …
underrepresented in this chemical space. However, genomics supports vast untapped …
A Cryptic Plant Terpene Cyclase Producing Unconventional 18‐ and 14‐Membered Macrocyclic C25 and C20 Terpenoids with Immunosuppressive Activity
YG Chen, DS Li, Y Ling, YC Liu, ZL Zuo… - Angewandte …, 2021 - Wiley Online Library
A versatile terpene synthase (LcTPS2) producing unconventional macrocyclic terpenoids
was characterized from Leucosceptrum canum. Engineered Escherichia coli and Nicotiana …
was characterized from Leucosceptrum canum. Engineered Escherichia coli and Nicotiana …
Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase
Z Li, L Zhang, K Xu, Y Jiang, J Du, X Zhang… - Nature …, 2023 - nature.com
Diterpene synthase VenA is responsible for assembling venezuelaene A with a unique 5-5-
6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also demonstrates …
6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also demonstrates …
Thermoadaptation in an ancestral diterpene cyclase by altered loop stability
Thermostability is the key to maintain the structural integrity and catalytic activity of enzymes
in industrial biotechnological processes, such as terpene cyclase-mediated generation of …
in industrial biotechnological processes, such as terpene cyclase-mediated generation of …
Switching Prenyl Donor Specificities in Squalene Synthase-Like Aromatic Prenyltransferases from Bacterial Carbazole Alkaloid Biosynthesis
Y Shen, L Zhang, M Yang, T Shi, Y Li, L Li… - ACS Chemical …, 2023 - ACS Publications
Lavanduquinocin (LDQ) is a potent neuroprotective carbazole alkaloid from Streptomyces
species that features a rare cyclic monoterpene/cyclolavandulyl moiety attached to the …
species that features a rare cyclic monoterpene/cyclolavandulyl moiety attached to the …
Mechanistic Insights into the Formation of the 6, 10‐Bicyclic Eunicellane Skeleton by the Bacterial Diterpene Synthase Bnd4
The eunicellane diterpenoids are a unique family of natural products seen in marine
organisms, plants, and bacteria. We used a series of biochemical, bioinformatics, and …
organisms, plants, and bacteria. We used a series of biochemical, bioinformatics, and …
Mutation of the eunicellane synthase Bnd4 alters its product profile and expands its prenylation ability
Bnd4 catalyzes the first committed step in the biosynthesis of the bacterial diterpenoid
benditerpenoic acid and was the first eunicellane synthase identified from nature. We …
benditerpenoic acid and was the first eunicellane synthase identified from nature. We …
Boswellianols A–I, Structurally Diverse Diterpenoids from the Oleo-Gum Resin of Boswellia carterii and Their TGF-β Inhibition Activity
Olibanum, a golden oleo-gum resin from species in the Boswellia genus (Burseraceae
family), is a famous traditional herbal medicine widely used around the world. Previous …
family), is a famous traditional herbal medicine widely used around the world. Previous …