Free radical generation occurs continuously within cells as a consequence of common
metabolic processes. However, in high concentrations, whether from endogenous or …

The main objectives of this study were to determine the influence of diets enriched in α-
linolenic, linoleic or oleic acid on the development and transcriptomic profile of embryos …

Cysteine sulfinic acid or S-sulfinylation is an oxidative post-translational modification
(OxiPTM) that is known to be involved in redox-dependent regulation of protein function but …

The purpose of the current study was to investigate the effect of the recently synthesized
mitochondrially-targeted H 2 S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1, 2-dithiol-5yl) …

Peroxiredoxins (Prxs) make up an ancient family of enzymes that are the predominant
peroxidases for nearly all organisms and play essential roles in reducing hydrogen …

Oxygen is the sustenance of aerobic life and yet is highly toxic. In early life, antioxidants
functioned solely to defend against toxic effects of reactive oxygen species (ROS). Later, as …

Background High-cholesterol diet (HCD) increases the oxidative stress in different tissues
leading to many diseases. Rutin (RT) is a natural flavonoid (vitamin p), which possesses an …

Cells must be able to respond and adapt to different stress conditions to maintain normal
function. A common response to stress is the global inhibition of protein synthesis. Protein …

Protein thiols play a crucial role in redox signaling, in the regulation of enzymatic activity and
protein function, and in maintaining redox homeostasis in living systems. The unique …

Nitro-oxidative stress and lowered antioxidant defences play a key role in neuropsychiatric
disorders such as major depression, bipolar disorder and schizophrenia. The first part of this …