Frequency of germline mutations in cancer susceptibility genes in malignant mesothelioma

V Panou, M Gadiraju, A Wolin, CM Weipert… - Journal of Clinical …, 2018 - ascopubs.org
Purpose The aim of the current study was to determine the prevalence and clinical
predictors of germline cancer susceptibility mutations in patients with malignant …

Asbestos-related cancers: the 'Hidden Killer'remains a global threat

N van Zandwijk, G Reid, AL Frank - Expert review of anticancer …, 2020 - Taylor & Francis
Introduction: Asbestos, the most frequent cause of occupational cancer, continues to be
consumed on a massive scale, with millions of people exposed on a daily basis. This review …

Current management and future perspective in pleural mesothelioma

R Shah, LV Klotz, J Glade - Cancers, 2022 - mdpi.com
Simple Summary Platin-based chemotherapy with pemetrexed has been the backbone of
meaningful treatment in pleural mesothelioma for the last 16 years, alongside vinorelbine …

Large‐scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma

A De Rienzo, LR Chirieac, YP Hung… - The Journal of …, 2021 - Wiley Online Library
Abstract BRCA1‐associated protein‐1 (BAP1) expression is commonly lost in several
tumors including malignant pleural mesothelioma (MPM). Presence or absence of …

Loss of BRCA1‐associated protein 1 (BAP 1) expression is useful in diagnostic cytopathology of malignant mesothelioma in effusions

I Cozzi, FA Oprescu, E Rullo… - Diagnostic …, 2018 - Wiley Online Library
Background The important diagnostic challenge facing the cytopathologist is whether a
mesothelial proliferation on effusions represents a malignant mesothelioma (MM) or a …

Novel LRRK2 mutations and other rare, non-BAP1-related candidate tumor predisposition gene variants in high-risk cancer families with mesothelioma and other …

M Cheung, Y Kadariya, E Sementino… - Human Molecular …, 2021 - academic.oup.com
There is irrefutable evidence that germline BRCA1-associated protein 1 gene (BAP1)
mutations contribute to malignant mesothelioma (MM) susceptibility. However, BAP1 …

Diagnostic value of BRCA1‐associated protein‐1, glucose transporter‐1 and desmin expression in the discrimination between reactive mesothelial proliferation and …

S Önder, E Özogul, D Koksal, S Sarinc Ulasli… - …, 2019 - Wiley Online Library
Objective The aim of this study was to investigate the utility of BRCA1‐associated protein‐1
(BAP 1), glucose transporter (GLUT)‐1 and desmin expression by immunohistochemistry in …

BRCA1-associated protein-1 suppresses osteosarcoma cell proliferation and migration through regulation PI3K/Akt pathway

S Gao, H Sun, C Cheng, G Wang - DNA and Cell Biology, 2017 - liebertpub.com
BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating
enzyme. Dysregulation of BAP1 has been reported in many types of cancers. However …

[HTML][HTML] Diagnostic, prognostic, and therapeutic implications of genetic profiling in pleural mesothelioma

A Sadek, A De Rienzo, R Bueno - Journal of Cancer Metastasis …, 2023 - oaepublish.com
Pleural mesothelioma (PM) is an aggressive malignancy of the pleural lining that typically
arises secondary to asbestos exposure. With the advent of next-generation sequencing …

What's new in mesothelioma

V Ascoli, B Murer, A Nottegar, C Luchini, R Carella… - Pathologica, 2018 - iris.uniroma1.it
Malignant pleural mesothelioma is a neoplasm characterized by a very poor prognosis and
medico-legal implications. Diagnosis, prognosis and therapy are often challenging and …