In recent years, the role of 53BP1 as a cell cycle regulator has come into the spotlight.
53BP1 is best understood for its role in controlling DNA double-strand break repair …

DNA-damaging agents and endogenous DNA damage constantly harm genome integrity.
Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in …

Mutations in the RNA helicase, DDX3X, are a leading cause of Intellectual Disability and
present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical …

Mutations in centrosome genes deplete neural progenitor cells (NPCs) during brain
development, causing microcephaly. While NPC attrition is linked to TP53‐mediated cell …

Biallelic loss-of-function variants in SMPD4 cause a rare and severe neurodevelopmental
disorder with progressive congenital microcephaly and early death. SMPD4 encodes a …

Centrosomes are dominant microtubule organizing centers in animal cells with a pair of
centrioles at their core. They template cilia during interphase and help organize the mitotic …

One of the biggest mysteries in neurobiology concerns the mechanisms responsible for the
diversification of the brain over different time scales, ie during development and evolution …

Microtubules that assemble the mitotic spindle are generated by centrosomal nucleation,
chromatin-mediated nucleation, and nucleation from the surface of other microtubules …

Dynein heavy chain (DYNC1H1) mutations can either lead to severe cerebral cortical
malformations, or alternatively may be associated with the development of spinal muscular …

Primary microcephaly is a brain growth disorder characterized by a severe reduction of brain
size and thinning of the cerebral cortex. Many primary microcephaly mutations occur in …