Stem cell therapies in cardiovascular disease

M Terashvili, ZJ Bosnjak - Journal of cardiothoracic and vascular …, 2019 - Elsevier
Despite considerable advances in medicine, cardiovascular disease is still rising, with
ischemic heart disease being the leading cause of death and disability worldwide. Thus …

Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients …

V Karantalis, DL DiFede, G Gerstenblith… - Circulation …, 2014 - Am Heart Assoc
Rationale: Although accumulating data support the efficacy of intramyocardial cell-based
therapy to improve left ventricular (LV) function in patients with chronic ischemic …

Targeting Wnt signaling through small molecules in governing stem cell fate and diseases

A Banerjee, G Jothimani, SV Prasad… - … Metabolic & Immune …, 2019 - ingentaconnect.com
Background: The conserved Wnt/β-catenin signaling pathway is responsible for multiple
functions including regulation of stem cell pluripotency, cell migration, self-renewability and …

Standardization and quality assessment for clinical grade mesenchymal stem cells from human adipose tissue

T Debnath, LK Chelluri - Hematology, Transfusion and Cell Therapy, 2019 - SciELO Brasil
Background Mesenchymal stem cells have immense potential in stem cell-based therapies,
however there is a pre-requisite to develop a curative cell dose. Adipose tissue-derived …

Effect of engineered superparamagnetic iron oxide nanoparticles in targeted cardiac precursor cell delivery by MRI

LK Chelluri, Y Mohanram, R Jain, CS Mallarpu… - Biochemical and …, 2021 - Elsevier
A scientific approach is presented describing the fabrication of nanoprobe (GloTrack) that
can act as cardiac precursor label to segregate cells from cardiac/non cardiac origins and …

Wnt signalling inhibitors potently drive trans-differentiation potential of mesenchymal stem cells towards neuronal lineage

A Banerjee, P Rowlo, G Jothimani, AK Duttaroy… - Journal of Medical and …, 2022 - Springer
Purpose To date to repair and restore the neurons in neurodegenerative disorders,
numerous approaches are addressed, but the retaining activities of those cells were not well …

Inorganic nanorods direct neuronal differentiation of bone marrow-derived mesenchymal stem cells

SK Vemuri, RR Banala, SK Nethi, VM Devraj… - Biomedical …, 2023 - iopscience.iop.org
Mesenchymal stem cells (MSCs) are multipotent cells and are considered a potential source
for tissue and organ repair due to their self-renewal, proliferation, and differentiation abilities …

In vitro assessment of cytotoxicity and labeling efficiency of 99mTc-HMPAO with stromal vascular fraction of adipose tissue

VK Verma, SS Beevi, A Tabassum… - Nuclear Medicine and …, 2014 - Elsevier
Introduction Noninvasive radionuclide imaging of cells using technetium99m-
hexamethylpropyleneamine oxime (99m Tc-HMPAO) is a potential diagnostic tool for …

Signal regulatory protein alpha (SIRPA) and kinase domain receptor (KDR) are key expression markers in cardiac specific precursor selection from hADSCs

VK Verma, SS Beevi, T Debnath, U Shalini… - New Horizons in …, 2015 - Elsevier
Background Cardiomyocyte enrichment strategies so far have not yielded scalable cardiac
specific cell type. More so, the current data is restricted to embryonic stem cells …

[HTML][HTML] A modified approach to image guided cell based therapy for cardiovascular diseases using cardiac precursor nanoprobe-GloTrack

LK Chelluri, R Jain, Y Mohanram, D Kumar… - 2016 - researchsquare.com
For cell based myocardial repair, a reliable and selective enrichment strategy of the cardiac
precursor cells is crucial. Herein, we describe a modified approach which is economical and …