Immune defense and reproduction are physiologically and energetically demanding
processes and have been observed to trade off in a diversity of female insects. Increased …

Advances in metabolomics have deepened our understanding of the roles that specific
modes of metabolism play in programming stem cell fates. Here, we review recent …

Skeletal stem cells (SSCs) that are the major source of osteoblasts and adipocytes in adult
bone marrow express leptin receptor (LepR). To test whether LepR regulates SSC function …

Choosing the right nutrients to consume is essential to health and wellbeing across species.
However, the factors that influence these decisions are poorly understood. This is …

Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …

Niches are local tissue microenvironments that maintain and regulate stem cells. Long-
predicted from mammalian studies, these structures have recently been characterized within …

Life history theory seeks to explain the evolution of the major features of life cycles by
analyzing the ecological factors that shape age-specific schedules of growth, reproduction …

Vertebrate and invertebrate digestive systems show extensive similarities in their
development, cellular makeup and genetic control. The Drosophila midgut is typical …

The concept that stem cells are controlled by particular microenvironments known as' niches'
has been widely invoked. But niches have remained largely a theoretical construct because …

Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and
rodents. In the nematode and the fly, secondary hormones downstream of insulin-like …