[HTML][HTML] The human connectome project: a retrospective
Abstract The Human Connectome Project (HCP) was launched in 2010 as an ambitious
effort to accelerate advances in human neuroimaging, particularly for measures of brain …
effort to accelerate advances in human neuroimaging, particularly for measures of brain …
Clinical use of current polygenic risk scores may exacerbate health disparities
Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …
medicine. However, the major ethical and scientific challenge surrounding clinical …
[HTML][HTML] Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies
Sažetak Calculating the sample size in scientific studies is one of the critical issues as
regards the scientific contribution of the study. The sample size critically affects the …
regards the scientific contribution of the study. The sample size critically affects the …
Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes
Genome-wide association studies have successfully discovered thousands of common
variants associated with human diseases and traits, but the landscape of rare variations in …
variants associated with human diseases and traits, but the landscape of rare variations in …
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield an inflated distribution of test statistics in …
relatedness and population stratification, can yield an inflated distribution of test statistics in …
Statistical power and significance testing in large-scale genetic studies
PC Sham, SM Purcell - Nature Reviews Genetics, 2014 - nature.com
Significance testing was developed as an objective method for summarizing statistical
evidence for a hypothesis. It has been widely adopted in genetic studies, including genome …
evidence for a hypothesis. It has been widely adopted in genetic studies, including genome …
Deep learning for plant genomics and crop improvement
Our era has witnessed tremendous advances in plant genomics, characterized by an
explosion of high-throughput techniques to identify multi-dimensional genome-wide …
explosion of high-throughput techniques to identify multi-dimensional genome-wide …
[PDF][PDF] Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
BIOINFORMATICS APPLICATIONS NOTE Vol. 19 no. 1 2003 Page 1 BIOINFORMATICS
APPLICATIONS NOTE Vol. 19 no. 1 2003 Pages 149–150 Genetic Power Calculator: design of …
APPLICATIONS NOTE Vol. 19 no. 1 2003 Pages 149–150 Genetic Power Calculator: design of …
Statistical power to detect genetic (co) variance of complex traits using SNP data in unrelated samples
We have recently developed analysis methods (GREML) to estimate the genetic variance of
a complex trait/disease and the genetic correlation between two complex traits/diseases …
a complex trait/disease and the genetic correlation between two complex traits/diseases …
Genome-wide association studies: theoretical and practical concerns
WYS Wang, BJ Barratt, DG Clayton… - Nature Reviews Genetics, 2005 - nature.com
To fully understand the allelic variation that underlies common diseases, complete genome
sequencing for many individuals with and without disease is required. This is still not …
sequencing for many individuals with and without disease is required. This is still not …