The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …

DNA double-strand breaks (DSBs) disrupt the continuity of chromosomes and their repair by
error-free mechanisms is essential to preserve genome integrity. Microhomology-mediated …

Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is
the fifth most common cancer worldwide and the third most common cause of cancer …

An ageing world population has fuelled interest in regenerative remedies that may stem
declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic …

The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

DNA double-strand breaks are normal consequences of cell division and differentiation and
must be repaired faithfully to maintain genome stability. Two mechanistically distinct …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

Fusion genes that are caused by chromosome translocations have been recognized for
several decades as drivers of deregulated cell growth in certain types of cancer. In recent …

Natural chromosome ends resemble double-stranded DNA breaks, but they do not activate
a damage response in healthy cells. Telomeres therefore have evolved to solve the'end …

Aberrant fusions between heterologous chromosomes are among the most prevalent
cytogenetic abnormalities found in cancer cells. Oncogenic chromosomal translocations …