Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Amyloid formation as a protein phase transition
The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …
is associated with both functional biology and the development of a number of disorders …
Physical principles underlying the complex biology of intracellular phase transitions
JM Choi, AS Holehouse… - Annual review of …, 2020 - annualreviews.org
Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …
have the hallmarks of intracellular phase transitions. This suggests that a common …
Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins
Intrinsically disordered proteins rich in cationic amino acid groups can undergo Liquid-
Liquid Phase Separation (LLPS) in the presence of charge-balancing anionic counterparts …
Liquid Phase Separation (LLPS) in the presence of charge-balancing anionic counterparts …
Polyelectrolyte complex coacervates: Recent developments and new frontiers
AM Rumyantsev, NE Jackson… - Annual Review of …, 2021 - annualreviews.org
Polyelectrolyte complex coacervates represent a wide class of materials with applications
ranging from coatings and adhesives to pharmaceutical technologies. They also underpin …
ranging from coatings and adhesives to pharmaceutical technologies. They also underpin …
TDP-43 α-helical structure tunes liquid–liquid phase separation and function
Liquid–liquid phase separation (LLPS) is involved in the formation of membraneless
organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is …
organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is …
LASSI: A lattice model for simulating phase transitions of multivalent proteins
Many biomolecular condensates form via spontaneous phase transitions that are driven by
multivalent proteins. These molecules are biological instantiations of associative polymers …
multivalent proteins. These molecules are biological instantiations of associative polymers …
Liquid–liquid phase separation by intrinsically disordered protein regions of viruses: Roles in viral life cycle and control of virus–host interactions
Intrinsically disordered proteins (IDPs) are unable to adopt a unique 3D structure under
physiological conditions and thus exist as highly dynamic conformational ensembles. IDPs …
physiological conditions and thus exist as highly dynamic conformational ensembles. IDPs …
Comparative roles of charge, π, and hydrophobic interactions in sequence-dependent phase separation of intrinsically disordered proteins
Endeavoring toward a transferable, predictive coarse-grained explicit-chain model for
biomolecular condensates underlain by liquid–liquid phase separation (LLPS) of proteins …
biomolecular condensates underlain by liquid–liquid phase separation (LLPS) of proteins …
Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior
Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the
formation of membraneless organelles, which compartmentalize molecules intracellularly in …
formation of membraneless organelles, which compartmentalize molecules intracellularly in …