A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides
KC Paul, RC Krolewski, E Lucumi Moreno… - Nature …, 2023 - nature.com
Parkinson's disease (PD) is a complex neurodegenerative disease with etiology rooted in
genetic vulnerability and environmental factors. Here we combine quantitative …
genetic vulnerability and environmental factors. Here we combine quantitative …
Modeling Parkinson's disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines
Abstract Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of
Parkinson's disease (PD) pathology, yet a cellular model for LB formation remains elusive …
Parkinson's disease (PD) pathology, yet a cellular model for LB formation remains elusive …
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
[HTML][HTML] alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propagation, aggregation, and the formation of inclusions
A Bayati, PS McPherson - Journal of Biological Chemistry, 2024 - Elsevier
Research into the pathophysiology of Parkinson's disease (PD) is a fast-paced pursuit, with
new findings about PD and other synucleinopathies being made each year. The …
new findings about PD and other synucleinopathies being made each year. The …
A dual hit of α-synuclein internalization and immune challenge leads to the formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons
Lewy bodies (LBs), rich in α-synuclein, are a hallmark of Parkinson's disease (PD).
Understanding their biogenesis is likely to provide insight into the pathophysiology of PD …
Understanding their biogenesis is likely to provide insight into the pathophysiology of PD …
[HTML][HTML] Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies
Whether neurodegenerative diseases linked to misfolding of the same protein share genetic
risk drivers or whether different protein-aggregation pathologies in neurodegeneration are …
risk drivers or whether different protein-aggregation pathologies in neurodegeneration are …
Proteostasis dysregulation in p. A53T-α-Synuclein iPSC-derived astrocytes exacerbates neurodegeneration in a Parkinson's disease model with Lewy-like pathology
C Paschou, O Apokotou, A Kollias, K Charmpi, S Dede… - bioRxiv, 2024 - biorxiv.org
Alpha-Synuclein (αSyn) plays a central role in Parkinson's disease (PD) and the p. A53T
mutation causes an early-onset familial form of PD with severe manifestations. The …
mutation causes an early-onset familial form of PD with severe manifestations. The …
Correlative light and electron microscopy for human brain and other biological models
N Shafiei, D Stӓhli, D Burger, M Di Fabrizio… - bioRxiv, 2024 - biorxiv.org
Correlative light and electron microscopy (CLEM) combines light microscopy, for identifying
a target via genetic labels, dyes, antibodies, and morphological features, with electron …
a target via genetic labels, dyes, antibodies, and morphological features, with electron …
Cholesterol Dysregulation in APOE4/4 Astrocytes Mediates α-Synuclein Pathology in an iPSC-Derived Model of Human Brain Tissue
C Goldman - 2024 - search.proquest.com
Synucleinopathies are a group of neurodegenerative diseases characterized by the
accumulation of α-Synuclein (α-Syn) into neurotoxic inclusions in the central nervous …
accumulation of α-Synuclein (α-Syn) into neurotoxic inclusions in the central nervous …
[PDF][PDF] A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic …
PS McPherson - researchgate.net
Lewy bodies (LBs), rich in α-synuclein, are a hallmark of Parkinson's disease (PD).
Understanding their biogenesis is likely to provide insight into the pathophysiology of PD …
Understanding their biogenesis is likely to provide insight into the pathophysiology of PD …