Adenoviral vectors (AdVs) are effective vectors for gene therapy due to their broad tropism,
large capacity, and high transduction efficiency, making them widely used as oncolytic …

Decades of basic and translational research have led to a momentum shift in dissecting the
relationship between immune cells and cancer. This culminated in the emergence of …

Cancer immunotherapy is focused on stimulating the immune system against cancer cells by
exploiting immune checkpoint mechanisms. PD-1/PD-L1 is one of the most known immune …

Immunotherapy has emerged as a promising approach for cancer treatment, with oncolytic
adenoviruses showing power as immunotherapeutic agents. In this study, we investigated …

Oncolytic viruses (OVs) are biological therapeutic agents that selectively destroy cancer
cells while sparing normal healthy cells. Besides direct oncolysis, OV infection induces a …

Cancer immunotherapy requires a specific antitumor CD8+ T cell-driven immune response;
however, upon genetic and epigenetic alterations of the antigen processing and presenting …

Background: co-targeting of immune checkpoint inhibitors (ICI) CTLA-4 and PD-1 has
recently become the new first-line standard of care therapy of pleural mesothelioma (PM) …