Organophosphate toxicity: Updates of malathion potential toxic effects in mammals and potential treatments

AM Badr - Environmental science and pollution research, 2020 - Springer
Organophosphorus insecticides toxicity is still considered a major global health problem.
Malathion is one of the most commonly used organophosphates nowadays, as being …

Novel clinical toxicology and pharmacology of organophosphorus insecticide self-poisoning

M Eddleston - Annual review of pharmacology and toxicology, 2019 - annualreviews.org
Organophosphorus insecticide self-poisoning is a major global health problem, killing over
100,000 people annually. It is a complex multi-organ condition, involving the inhibition of …

Toxic effects of pesticide mixtures at a molecular level: their relevance to human health

AF Hernández, T Parrón, AM Tsatsakis, M Requena… - Toxicology, 2013 - Elsevier
Pesticides almost always occur in mixtures with other ones. The toxicological effects of low-
dose pesticide mixtures on the human health are largely unknown, although there are …

Organophosphorus pesticides can influence the development of obesity and type 2 diabetes with concomitant metabolic changes

M Czajka, M Matysiak-Kucharek… - Environmental …, 2019 - Elsevier
Widespread use and the bioaccumulation of pesticides in the environment lead to the
contamination of air, water, soil and agricultural resources. A huge body of evidence points …

The pipeline for drugs for control and elimination of neglected tropical diseases: 1. Anti-infective drugs for regulatory registration

KM Pfarr, AK Krome, I Al-Obaidi, H Batchelor… - Parasites & …, 2023 - Springer
Abstract The World Health Organization 'Ending the neglect to attain the Sustainable
Development Goals: A road map for neglected tropical diseases 2021–2030'outlines the …

Protective effects of thymoquinone and diallyl sulphide against malathion-induced toxicity in rats

MM Abdel-Daim, AI Abushouk, SG Bungău… - … Science and Pollution …, 2020 - Springer
Malathion is a potent organophosphate insecticide that inhibits acetylcholinesterase (AChE)
enzyme. Our experimental objective was to investigate the beneficial effects of diallyl …

Comprehensive investigation of the mutagenic potential of six pesticides classified by IARC as probably carcinogenic to humans

R Martinek, R Lózsa, Á Póti, E Németh, G Várady… - Chemosphere, 2024 - Elsevier
Pesticides are significant environmental pollutants, and many of them possess mutagenic
potential, which is closely linked to carcinogenesis. Here we tested the mutagenicity of all six …

Antioxidant and anti-inflammatory effects of N-acetylcysteine against malathion-induced liver damages and immunotoxicity in rats

MM Lasram, AJ Lamine, IB Dhouib, K Bouzid, A Annabi… - Life sciences, 2014 - Elsevier
Aims Occupational exposure to organophosphate pesticides is becoming a common and
increasingly alarming world-wide phenomenon. The present study is designed to investigate …

A review on the molecular mechanisms involved in insulin resistance induced by organophosphorus pesticides

MM Lasram, IB Dhouib, A Annabi, S El Fazaa, N Gharbi - Toxicology, 2014 - Elsevier
There is increasing evidence reporting that organophosphorus pesticides (OPs) impair
glucose homeostasis and cause insulin resistance and type 2 diabetes. Insulin resistance is …

Caco-2/TC7 cell line characterization for intestinal absorption: how reliable is this in vitro model for the prediction of the oral dose fraction absorbed in human?

L Turco, T Catone, F Caloni, E Di Consiglio, E Testai… - Toxicology in vitro, 2011 - Elsevier
Caco-2 cell line is one of the most used in vitro model to study intestinal absorption of
compounds at screening level. Several clones have been isolated from Caco-2 cell line and …