Microbiome and human health: current understanding, engineering, and enabling technologies

N Aggarwal, S Kitano, GRY Puah, S Kittelmann… - Chemical …, 2022 - ACS Publications
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

A systematic review of antibiotics and antibiotic resistance genes in estuarine and coastal environments

D Zheng, G Yin, M Liu, C Chen, Y Jiang, L Hou… - Science of the Total …, 2021 - Elsevier
Antibiotics and antibiotic resistance genes (ARGs) are prevalent in estuarine and coastal
environments due to substantial terrestrial input, aquaculture effluent, and sewage …

[HTML][HTML] Understanding the impact of antibiotic perturbation on the human microbiome

DJ Schwartz, AE Langdon, G Dantas - Genome medicine, 2020 - Springer
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses
that performs essential functions for immune development, pathogen colonization …

[PDF][PDF] Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adults

WE Anthony, B Wang, KV Sukhum, AW D'Souza… - Cell reports, 2022 - cell.com
Antibiotics are deployed against bacterial pathogens, but their targeting of conserved
microbial processes means they also collaterally perturb the commensal microbiome. To …

Recovery of gut microbiota of healthy adults following antibiotic exposure

A Palleja, KH Mikkelsen, SK Forslund, A Kashani… - Nature …, 2018 - nature.com
To minimize the impact of antibiotics, gut microorganisms harbour and exchange antibiotics
resistance genes, collectively called their resistome. Using shotgun sequencing-based …

Gut bacteria composition drives primary resistance to cancer immunotherapy in renal cell carcinoma patients

L Derosa, B Routy, M Fidelle, V Iebba, L Alla, E Pasolli… - European urology, 2020 - Elsevier
Background The development of immune checkpoint blockade (ICB) has revolutionized the
clinical outcome of renal cell carcinoma (RCC). Nevertheless, improvement of durability and …

Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health

M Fassarella, EE Blaak, J Penders, A Nauta, H Smidt… - Gut, 2021 - gut.bmj.com
The human gut microbiome is a complex ecosystem, densely colonised by thousands of
microbial species. It varies among individuals and depends on host genotype and …

[PDF][PDF] The human gut microbiome: from association to modulation

TSB Schmidt, J Raes, P Bork - Cell, 2018 - cell.com
Our understanding of the human gut microbiome continues to evolve at a rapid pace, but
practical application of thisknowledge is still in its infancy. This review discusses the type of …

Codiversification of gut microbiota with humans

TA Suzuki, JL Fitzstevens, VT Schmidt, H Enav… - Science, 2022 - science.org
The gut microbiomes of human populations worldwide have many core microbial species in
common. However, within a species, some strains can show remarkable population …