The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

Intense interest in the'Warburg effect'has been revived by the discovery that hypoxia-
inducible factor 1 (HIF1) reprogrammes pyruvate oxidation to lactic acid conversion; lactic …

The mechanisms underlying the progression of diabetes mellitus and heart failure are
closely intertwined, such that worsening of one condition is frequently accompanied by …

Alterations in tumour metabolism and acid/base regulation result in the formation of a hostile
environment, which fosters tumour growth and metastasis. Acid/base homoeostasis in …

Cancer cells acquire an unusual glycolytic behavior relative, to a large extent, to their
intracellular alkaline pH (pH i). This effect is part of the metabolic alterations found in most, if …

Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …

Abstract Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases
which are best known for their ability to proteolyse extracellular matrix proteins throughout …

Although cancer is characterized by an intratumoral genetic heterogeneity, a totally
deranged pH control is a common feature of most cancer histotypes. Major determinants of …

Intracellular pH (pHi) is an important modulator of cardiac excitation and contraction, and a
potent trigger of electrical arrhythmia. This review outlines the intracellular and membrane …

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities
for therapeutic intervention. The acidic microenvironment within a tumour can promote …