Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems

Z Chen, MA Farag, Z Zhong, C Zhang, Y Yang… - Advanced drug delivery …, 2021 - Elsevier
As naturally occurring bioactive products, several lines of evidence have shown the potential
of polyphenols in the medical intervention of various diseases, including tumors …

High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury

W Li, J Chen, S Zhao, T Huang, H Ying… - Nature …, 2022 - nature.com
Drug delivery systems with high content of drug can minimize excipients administration,
reduce side effects, improve therapeutic efficacy and/or promote patient compliance …

pH switchable nanoplatform for in vivo persistent luminescence imaging and precise photothermal therapy of bacterial infection

LX Yan, LJ Chen, X Zhao… - Advanced Functional …, 2020 - Wiley Online Library
Photothermal therapy (PTT) is one of the most promising approaches to combat multidrug‐
resistant bacteria with less potential to induce resistance and systemic toxicity. However …

Preparation, characterization and antioxidant activity of protocatechuic acid grafted carboxymethyl chitosan and its hydrogel

C Xu, S Guan, J Xu, W Gong, T Liu, X Ma, C Sun - Carbohydrate Polymers, 2021 - Elsevier
In this study, protocatechuic acid (PCA) was grafted onto carboxymethyl chitosan (CMCS)
via EDC/NHS to improve the antioxidant effect. The grafting ratio of PCA-g-CMCS …

Regenerative therapies for spinal cord injury

N Ashammakhi, HJ Kim, A Ehsanipour… - … Engineering Part B …, 2019 - liebertpub.com
Spinal cord injury (SCI) is a serious problem that primarily affects younger and middle-aged
adults at its onset. To date, no effective regenerative treatment has been developed. Over …

Ferulic acid: a hope for Alzheimer's disease therapy from plants

A Sgarbossa, D Giacomazza, M Di Carlo - Nutrients, 2015 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of
extracellular amyloid-beta peptide (Aβ) and intracellular neurofibrillar tangles, associated …

Polyphenol-chitosan conjugates: Synthesis, characterization, and applications

Q Hu, Y Luo - Carbohydrate polymers, 2016 - Elsevier
Chitosan, the only positively charged polysaccharide in the world, is very attractive for food,
medicinal and pharmaceutical applications because of its promising properties, including …

Applications of chitosan-based biomaterials: From preparation to spinal cord injury neuroprosthetic treatment

W Xiang, H Cao, H Tao, L Jin, Y Luo, F Tao… - International Journal of …, 2023 - Elsevier
Spinal cord injury (SCI)-related disabilities are a serious problem in the modern society.
Further, the treatment of SCI is highly challenging and is urgently required in clinical …

Role of phenolic compounds in human disease: current knowledge and future prospects

MM Rahman, MS Rahaman, MR Islam, F Rahman… - Molecules, 2021 - mdpi.com
Inflammation is a natural protective mechanism that occurs when the body's tissue
homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune …