Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Substrate inhibition of enzymes can be a major obstacle to the production of valuable
chemicals in engineered microorganisms. Here, we show substrate inhibition of lycopene …

Adaptive laboratory evolution (ALE) is an innovative approach for the generation of evolved
microbial strains with desired characteristics, by implementing the rules of natural selection …

Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Current energy security and climate change policies encourage the development and
utilization of bioenergy. Oleaginous yeasts provide a particularly attractive platform for the …

Saccharomyces cerevisiae is an efficient host for natural-compound production and
preferentially employed in academic studies and bioindustries. However, S. cerevisiae …

Metabolic engineering approaches for the production of high-value chemicals in
microorganisms mostly use the cytosol as general reaction vessel. However, sequestration …

Among non-conventional yeasts of industrial interest, the dimorphic oleaginous yeast
Yarrowia lipolytica appears as one of the most attractive for a large range of white …

Engineering microbes to produce terpenes from renewable feedstock is a promising
alternative to traditional production approaches. Generally, terpenes are not readily secreted …