Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side
effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically …

Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective
drugs successfully employed (alone or in combinations) as first-line treatment for common …

Anti-cancer drugs such as vincristine, paclitaxel, oxaliplatin, cisplatin and bortezomib are
well reported to exert direct and indirect effects on sensory nerves to alter the amplitude of …

Human acute and inflammatory pain requires the expression of voltage-gated sodium
channel Nav1. 7 but its significance for neuropathic pain is unknown. Here we show that …

The mitochondrial dysfunction has a critical role in several disorders including
chemotherapy-induced peripheral neuropathies (CIPN). This is due to a related …

In the human genome more than 400 genes encode ion channels, which are
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …

Animal models have provided useful insights into the development and treatment of
neuropathic pain. New genetic data from both human studies and transgenic mouse models …

Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapics
such as taxanes, vinca alkaloids, and platinum compounds. In recent years, several reports …

The burdensome condition of chemotherapy-induced peripheral neuropathy occurs with
various chemotherapeutics, including bortezomib, oxaliplatin, paclitaxel and vincristine. The …

Various ion channels are expressed in human cancers where they are intimately involved in
proliferation, angiogenesis, invasion and metastasis. Expression of functional voltage-gated …