The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

Protein ubiquitination is of great cellular importance through its central role in processes
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …

Regulated cellular proteolysis is mediated largely by the ubiquitin–proteasome system
(UPS). It is a highly specific process that is time-(eg cell cycle), compartment-(eg nucleus or …

Post-translational protein modifications initiate, regulate, propagate and terminate a wide
variety of processes in cells, and in particular, ubiquitylation targets substrate proteins for …

The ubiquitin–proteasome system (UPS) is involved in multiple cellular functions including
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …

Abstract The Ubiquitin Proteasome System (UPS) was discovered in two steps. Initially, APF-
1 (ATP-dependent proteolytic Factor 1) later identified as ubiquitin (Ub), a hitherto known …

Neurons, astrocytes and oligodendrocytes arise from CNS progenitor cells at defined times
and locations during development, with transcription factors serving as key determinants of …

Over thirty years have passed since the first description of ubiquitin-positive structures in the
brain of patients suffering from Alzheimer's disease. Meanwhile, the intracellular …

Ubiquitination of the αN-terminus of protein substrates has been reported sporadically since
the early 1980s. However, the identity of an enzyme responsible for this unique ubiquitin …

A polyubiquitin chain attached covalently to the target substrate has been recognized for
long as the “canonical” proteasomal degradation signal. However, several proteins have …