Photopharmacology is an attractive approach for achieving targeted drug action with the use
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …

Synthetic photoswitches have been known for many years, but their usefulness in biology,
pharmacology, and medicine has only recently been systematically explored. Over the past …

Conspectus Light is a fascinating phenomenon that ties together physics, chemistry, and
biology. It is unmatched in its ability to confer information with temporal and spatial precision …

Pharmacotherapy is often severely hindered by issues related to poor drug selectivity,
including side effects, environmental toxicity, and the emergence of resistance. Lack of …

Controlling the conformation and activity of biomolecules in a reversible manner is a
fascinating challenge (1-3) that has an outstanding potential for the study of and interference …

The field of photopharmacology aims to introduce smart drugs that, through the
incorporation of molecular photoswitches, allow for the remote spatial and temporal control …

Control over molecular motion represents an important objective in modern chemistry.
Aromatic azobenzenes are excellent candidates as molecular switches since they can exist …

Light-controllable tools provide powerful means to manipulate and interrogate brain function
with relatively low invasiveness and high spatiotemporal precision. Although optogenetic …

Reversibly altering endogenous protein levels are persistent issues. Herein, we designed
photoswitchable azobenzene-proteolysis targeting chimeras (Azo-PROTACs) by including …

Degenerative retinal diseases such as retinitis pigmentosa (RP) and age-related macular
degeneration (AMD) affect millions of people around the world and lead to irreversible vision …