Highlights•Astrocytes play crucial roles in establishing neural circuits during
development.•The onset of astrogenesis is temporally regulated.•Extrinsic cues and intrinsic …

The basic helix–loop–helix transcription factors oligodendrocyte transcription factor 1
(OLIG1) and OLIG2 are structurally similar and, to a first approximation, coordinately …

Down syndrome (DS), caused by trisomy of chromosome 21, occurs in 1 of every 800 live
births. Early defects in cortical development likely account for the cognitive impairments in …

Down syndrome (trisomy 21) is the most common viable chromosomal disorder with
intellectual impairment and several other developmental abnormalities. Here, we report the …

Down syndrome (DS) is a genetic disease that occurs due to an aneuploidy of human
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …

Down syndrome is the most common genetic developmental disorder in humans and is
caused by partial or complete triplication of human chromosome 21 (trisomy 21). It is a …

Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

Those with Down syndrome (DS)—trisomy for chromosome 21—are routinely impacted by
cognitive dysfunction and behavioral challenges in children and adults and Alzheimer's …

Although Down syndrome (DS), the most common developmental genetic cause of
intellectual disability, displays proliferation and migration deficits in the prenatal frontal …

The Olig genes encode members of the basic helix-loop-helix (bHLH) family of transcription
factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central …