Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity
B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …
An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment
J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications
B Zingales, MA Miles, DA Campbell… - Infection, genetics and …, 2012 - Elsevier
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …
nature for millions of years. The human infection, named Chagas disease, is a major public …
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance
Visceral leishmaniasis is a potentially fatal disease endemic to large parts of Asia and Africa,
primarily caused by the protozoan parasite Leishmania donovani. Here, we report a high …
primarily caused by the protozoan parasite Leishmania donovani. Here, we report a high …
International Study to Evaluate PCR Methods for Detection of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients
AG Schijman, M Bisio, L Orellana, M Sued… - PLoS neglected …, 2011 - journals.plos.org
Background A century after its discovery, Chagas disease still represents a major neglected
tropical threat. Accurate diagnostics tools as well as surrogate markers of parasitological …
tropical threat. Accurate diagnostics tools as well as surrogate markers of parasitological …
Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease
B Zingales, DC Bartholomeu - Memórias do instituto oswaldo cruz, 2022 - SciELO Brasil
Trypanosoma cruzi, the agent of Chagas disease (ChD), exhibits remarkable biological and
genetic diversity, along with eco-epidemiological complexity. In order to facilitate …
genetic diversity, along with eco-epidemiological complexity. In order to facilitate …
Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease
LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …
Pathogenesis of chagas' disease: parasite persistence and autoimmunity
ARL Teixeira, MM Hecht, MC Guimaro… - Clinical microbiology …, 2011 - Am Soc Microbiol
Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected
individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast …
individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast …
Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and …
Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …
and development for Chagas disease, a chronic infection caused by the genetically …
The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future
Trypanosoma cruzi is the protozoan agent of Chagas disease, and the most important
parasitic disease in Latin America. Protozoa of the genus Leishmania are global agents of …
parasitic disease in Latin America. Protozoa of the genus Leishmania are global agents of …