Chronic hyperglycemia is one of the main characteristics of diabetes. Persistent exposure to
elevated glucose levels has been recognized as one of the major causal factors of diabetic …

Background—Metabolic and vascular disturbances contribute to diabetic cardiomyopathy,
but the role of interstitial fibrosis in early disease is unproven. We sought to assess the …

The aim of this study is to investigate the mechanisms linking high glucose to gingival
wound healing. Bilateral wounds were created in the palatal gingiva adjacent to maxillary …

Extracellular matrix (ECM) has been a central topic in aging research for several years. Cell–
matrix interactions extend the interest in this topic both for normal tissue homeostatic …

Diabetic foot ulcers (DFU) are a major, debilitating complication of diabetes mellitus.
Unfortunately, many DFUs are refractory to existing treatments and frequently lead to …

Cardiovascular complications are a leading cause of death in patients with type 2 diabetes
mellitus (T2DM). Diastolic dysfunction is one of the earliest manifestations of diabetes …

Insulin dependent diabetes mellitus, marked by high blood glucose levels and no insulin
secretion, is associated with decreased bone mass and increased fracture rates. Analysis of …

Fibroblasts are a major cell population that perform critical functions in the wound healing
process. In response to injury, they proliferate and migrate into the wound space, engaging …

Identifying effective anti-aging compounds is a cornerstone of modern longevity, aging, and
skin-health research. There is considerable evidence of the effectiveness of nutrient …

Delayed wound healing is one of the most challenging complications of diabetes mellitus
(DM) in clinical medicine. This study has aimed to evaluate the effects of low-level laser …