Implications of peptide assemblies in amyloid diseases
Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …
quality of life of millions worldwide, with profound social and economic implications. Despite …
C-peptide replacement therapy as an emerging strategy for preventing diabetic vasculopathy
Lack of C-peptide, along with insulin, is the main feature of Type 1 diabetes mellitus (DM)
and is also observed in progressive β-cell loss in later stage of Type 2 DM. Therapeutic …
and is also observed in progressive β-cell loss in later stage of Type 2 DM. Therapeutic …
The intramolecular chaperone-mediated protein folding
YJ Chen, M Inouye - Current opinion in structural biology, 2008 - Elsevier
Some proteins have evolved to contain a specific sequence as an intramolecular
chaperone, which is essential for protein folding but not required for protein function, as it is …
chaperone, which is essential for protein folding but not required for protein function, as it is …
Novel nano-insulin formulation modulates cytokine secretion and remodeling to accelerate diabetic wound healing
Little is known about insulin's wound healing capability in normal as well as diabetic
conditions. We here report specific interaction of silver nanoparticles (AgNPs) with insulin by …
conditions. We here report specific interaction of silver nanoparticles (AgNPs) with insulin by …
Insulin Promotes Wound Healing by Inactivating NFkβP50/P65 and Activating Protein and Lipid Biosynthesis and alternating Pro/Anti-inflammatory Cytokines …
P Kaur, D Choudhury - Biomolecular Concepts, 2019 - degruyter.com
Four hundred and twenty-two million people have diabetes due to excess free body glucose
in their body fluids. Diabetes leads to various problems including retinopathy, neuropathy …
in their body fluids. Diabetes leads to various problems including retinopathy, neuropathy …
Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects
J Shafqat, E Melles, K Sigmundsson… - Cellular and Molecular …, 2006 - Springer
Using surface plasmon resonance (SPR) and electrospray mass spectrometry (ESI-MS),
proinsulin C-peptide was found to influence insulin-insulin interactions. In SPR with chip …
proinsulin C-peptide was found to influence insulin-insulin interactions. In SPR with chip …
[HTML][HTML] Dissecting the role of glutamine in seeding peptide aggregation
Poly glutamine and glutamine-rich peptides play a central role in a plethora of pathological
aggregation events. However, biophysical characterization of soluble oligomers-the most …
aggregation events. However, biophysical characterization of soluble oligomers-the most …
Biological activity versus physiological function of proinsulin C-peptide
M Landreh, H Jörnvall - Cellular and Molecular Life Sciences, 2021 - Springer
Proinsulin C-peptide (C-peptide) has drawn much research attention. Even if the peptide
has turned out not to be important in the treatment of diabetes, every phase of C-peptide …
has turned out not to be important in the treatment of diabetes, every phase of C-peptide …
Proinflammatory effects of C‐peptide in different tissues
D Vasic, D Walcher - International journal of inflammation, 2012 - Wiley Online Library
Atherosclerosis is well known as an inflammatory disease that can lead to clinical
complications such as heart attack or stroke. C‐peptide as a cleavage product of proinsulin …
complications such as heart attack or stroke. C‐peptide as a cleavage product of proinsulin …