Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …

Minipuberty consists of activation of the hypothalamic-pituitary-gonadal (HPG) axis during
the neonatal period, resulting in high gonadotropin and sex steroid levels, and occurs …

Primary ovarian insufficiency (POI) is determined by exhaustion of follicles in the ovaries,
which leads to infertility before the age of 40 years. It is characterized by a strong familial …

Reproduction cannot take place without the proper functioning of the lutropin/
choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does …

Premature ovarian failure (POF) causing hypergonadotrophic hypogonadism occurs in 1%
of women. In majority of cases the underlying cause is not identified. The known causes …

Primary ovarian insufficiency (POI) is characterized by a loss of ovarian function before the
age of 40 and account for one major cause of female infertility. POI relevance is continuously …

The recent unraveling of structures of genes for the gonadotropin subunits and gonadotropin
receptors has provided reproductive endocrinologists with new tools to study normal and …

Premature ovarian failure (POF) is a disorder with a complicated clinical presentation and
course that is poorly defined by its name. A more scientifically accurate term for the disorder …

LH and chorionic gonadotropin (CG) are glycoproteins fundamental to sexual development
and reproduction. Because they act on the same receptor (LHCGR), the general consensus …

Manipulation of Human Ovarian Function: Physiological Concepts and Clinical
Consequences* | Endocrine Reviews | Oxford Academic Skip to Main Content …