[HTML][HTML] The multi-functional calcium/calmodulin stimulated protein kinase (CaMK) family: emerging targets for anti-cancer therapeutic intervention
JS Brzozowski, KA Skelding - Pharmaceuticals, 2019 - mdpi.com
The importance of Ca2+ signalling in key events of cancer cell function and tumour
progression, such as proliferation, migration, invasion and survival, has recently begun to be …
progression, such as proliferation, migration, invasion and survival, has recently begun to be …
Polymer‐mediated gene therapy: Recent advances and merging of delivery techniques
JW Salameh, L Zhou, SM Ward… - Wiley …, 2020 - Wiley Online Library
The ability to safely and precisely deliver genetic materials to target sites in complex
biological environments is vital to the success of gene therapy. Numerous viral and nonviral …
biological environments is vital to the success of gene therapy. Numerous viral and nonviral …
Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma
Osteosarcoma (OS) is a highly aggressive pediatric cancer, characterized by frequent lung
metastasis and pathologic bone destruction. Vascular endothelial growth factor A (VEGFA) …
metastasis and pathologic bone destruction. Vascular endothelial growth factor A (VEGFA) …
RETRACTED: CRISPR/Cas9: A revolutionary genome editing tool for human cancers treatment
Cancer is a genetic disease stemming from genetic and epigenetic mutations and is the
second most common cause of death across the globe. Clustered regularly interspaced …
second most common cause of death across the globe. Clustered regularly interspaced …
[HTML][HTML] Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells
RH de Wit, A Mujić-Delić, JR van Senten… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The human cytomegalovirus (HCMV) encoded chemokine receptor US28 promotes
tumorigenesis through activation of various proliferative and angiogenic signaling pathways …
tumorigenesis through activation of various proliferative and angiogenic signaling pathways …
[HTML][HTML] MicroRNA-20b downregulates HIF-1α and inhibits the proliferation and invasion of osteosarcoma cells
M Liu, D Wang, N Li - Oncology research, 2016 - ncbi.nlm.nih.gov
Osteosarcoma (OS) is the most common malignant primary bone tumor disease. HIF-1α was
predicted to be the target gene of microRNA-20b (miR-20b). The present study was …
predicted to be the target gene of microRNA-20b (miR-20b). The present study was …
[HTML][HTML] Extracellular nanovesicles secreted by human osteosarcoma cells promote angiogenesis
Angiogenesis involves a number of different players among which extracellular
nanovesicles (EVs) have recently been proposed as an efficient cargo of pro-angiogenic …
nanovesicles (EVs) have recently been proposed as an efficient cargo of pro-angiogenic …
[HTML][HTML] Comparison of VEGF-A secretion from tumor cells under cellular stresses in conventional monolayer culture and microfluidic three-dimensional spheroid …
S Sarkar, CC Peng, YC Tung - PLoS One, 2020 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a major cytokine in tumor biology affecting
tumor survival, aggressiveness and pro-angiogenetic activities. In addition, cellular stresses …
tumor survival, aggressiveness and pro-angiogenetic activities. In addition, cellular stresses …
[HTML][HTML] Advances in intracellular calcium signaling reveal untapped targets for cancer therapy
Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating,
storage, and transport mechanisms are required to maintain normal cellular physiology …
storage, and transport mechanisms are required to maintain normal cellular physiology …
Up-regulation of pro-angiogenic molecules and events does not relate with an angiogenic switch in metastatic osteosarcoma cells but to cell survival features
LM Gutiérrez, M Valenzuela Alvarez, Y Yang, F Spinelli… - Apoptosis, 2021 - Springer
Osteosarcoma (OS) is the most frequent malignant bone tumor, affecting predominantly
children. Metastases represent a major clinical challenge and an estimated 80% would …
children. Metastases represent a major clinical challenge and an estimated 80% would …