The importance of Ca2+ signalling in key events of cancer cell function and tumour
progression, such as proliferation, migration, invasion and survival, has recently begun to be …

The ability to safely and precisely deliver genetic materials to target sites in complex
biological environments is vital to the success of gene therapy. Numerous viral and nonviral …

Osteosarcoma (OS) is a highly aggressive pediatric cancer, characterized by frequent lung
metastasis and pathologic bone destruction. Vascular endothelial growth factor A (VEGFA) …

Cancer is a genetic disease stemming from genetic and epigenetic mutations and is the
second most common cause of death across the globe. Clustered regularly interspaced …

The human cytomegalovirus (HCMV) encoded chemokine receptor US28 promotes
tumorigenesis through activation of various proliferative and angiogenic signaling pathways …

Osteosarcoma (OS) is the most common malignant primary bone tumor disease. HIF-1α was
predicted to be the target gene of microRNA-20b (miR-20b). The present study was …

Angiogenesis involves a number of different players among which extracellular
nanovesicles (EVs) have recently been proposed as an efficient cargo of pro-angiogenic …

Vascular endothelial growth factor (VEGF) is a major cytokine in tumor biology affecting
tumor survival, aggressiveness and pro-angiogenetic activities. In addition, cellular stresses …

Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating,
storage, and transport mechanisms are required to maintain normal cellular physiology …

Osteosarcoma (OS) is the most frequent malignant bone tumor, affecting predominantly
children. Metastases represent a major clinical challenge and an estimated 80% would …