Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of
nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize …

The Notch signaling pathway acts in both physiological and pathological conditions,
including embryonic development and tumorigenesis. In cancer progression, diverse …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that
dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). This complex binds to …

Macroautophagy/autophagy is vital for intracellular quality control and homeostasis.
Therefore, careful regulation of autophagy is very important. In the past 10 years, a number …

The molecular mechanisms underlying the development of thyroid cancer (TC) have been
examined through extensive experiments. A large number of studies have shown that the …

Abstract Di-(2-ethylhexyl)-phthalate (DEHP) accumulates in the environment, and its
exposure is possibly associated with endocrine-related disease in women of reproductive …

Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most
common cancer among women worldwide. Challenges facing the diagnosis and treatment …

Background The incidence of papillary thyroid cancer (PTC) is markedly higher in women
than men during the reproductive years. In vitro studies have suggested that estrogen may …

Bisphenol A (BPA) is a widespread endocrine disrupter mainly used in food contact plastics.
Much evidence supports the adverse effects of BPA, particularly on susceptible groups such …

The occurrence of colorectal cancer (CRC) is inversely correlated with estrogen receptor
beta (ERβ) presence. Additionally, multiple studies associate low ERβ expression with …