Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal lobar
degeneration (FTD), Lewy body disease (LBD), Parkinson's disease (PD), and amyotrophic …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …

Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs)
is the neurpathological hallmark of Parkinson's disease (PD) and related synucleinopathies …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …