Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

In the wake of the worldwide increase in type-2 diabetes, a major focus of research is
understanding the signaling pathways impacting this disease. Insulin signaling regulates …

Adipocytes have been studied with increasing intensity as a result of the emergence of
obesity as a serious public health problem and the realization that adipose tissue serves as …

Simultaneous inhibition of the acetyl-CoA carboxylase (ACC) isozymes ACC1 and ACC2
results in concomitant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation …

The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …

Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal
insufficiency more than 80 years ago, glucocorticoids (GC) and their cognate, intracellular …

Over the years, p53 has been shown to sit at the centre of an increasingly complex web of
incoming stress signals and outgoing effector pathways. The number and diversity of stress …

Kinases control virtually all aspects of biology. Forty-eight human proteins have a kinase-like
domain that lacks at least one of the conserved catalytic residues; these proteins are …

Dysregulated microglia are intimately involved in neurodegeneration, including Alzheimer's
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …

Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor,
initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism …