RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …

Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and progression of
colorectal cancer (CRC). However, functions of most lncRNAs in CRC and their molecular …

Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

Genomes of complex organisms encode an abundance and diversity of long noncoding
RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory …

Riboswitches were discovered in 2002 in bacteria as RNA-based intracellular sensors of
vitamin derivatives. During the last decade, naturally occurring RNA sensor elements have …

Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the
mammalian genome, many of which have important roles in regulating a variety of biological …

Pervasive transcription occurs in the human genome to generate thousands of RNA
transcripts, and accumulating evidence suggested that the RNA molecules, without protein …

Innate immune responses combat infectious microorganisms by inducing inflammatory
responses, antimicrobial pathways and adaptive immunity. Multiple genes within each of …

Non-protein-coding transcripts have been conserved throughout evolution, indicating that
crucial functions exist for these RNAs. For example, microRNAs (miRNAs) have been found …

RNA structure is crucial for gene regulation and function. In the past, transcriptomes have
largely been parsed by primary sequences and expression levels, but it is now becoming …