Telomere dysfunction in ageing and age-related diseases
Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …
dysfunction. Telomere shortening and damage are recognized causes of cellular …
Chemistry, structure and function of approved oligonucleotide therapeutics
M Egli, M Manoharan - Nucleic Acids Research, 2023 - academic.oup.com
Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …
[HTML][HTML] Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of …
KL Ong, LK Stafford, SA McLaughlin, EJ Boyko… - The Lancet, 2023 - thelancet.com
Background Diabetes is one of the leading causes of death and disability worldwide, and
affects people regardless of country, age group, or sex. Using the most recent evidentiary …
affects people regardless of country, age group, or sex. Using the most recent evidentiary …
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
Background Given the projected trends in population ageing and population growth, the
number of people with dementia is expected to increase. In addition, strong evidence has …
number of people with dementia is expected to increase. In addition, strong evidence has …
Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis …
JM Kocarnik, K Compton, FE Dean, W Fu… - JAMA …, 2022 - jamanetwork.com
Importance The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD
2019) provided systematic estimates of incidence, morbidity, and mortality to inform local …
2019) provided systematic estimates of incidence, morbidity, and mortality to inform local …
The path to healthy ageing in China: a Peking University–Lancet Commission
Executive summary Around the world, populations are ageing at a faster pace than in the
past and this demographic transition will have effects on all aspects of societies. In May …
past and this demographic transition will have effects on all aspects of societies. In May …
Chronic kidney disease
Chronic kidney disease is a progressive disease with no cure and high morbidity and
mortality that occurs commonly in the general adult population, especially in people with …
mortality that occurs commonly in the general adult population, especially in people with …
The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030
Cardiovascular disease is the leading cause of death in women. Decades of grassroots
campaigns have helped to raise awareness about the impact of cardiovascular disease in …
campaigns have helped to raise awareness about the impact of cardiovascular disease in …
The state of health in Pakistan and its provinces and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
A Hafeez, WJ Dangel, SM Ostroff, AG Kiani… - The Lancet Global …, 2023 - thelancet.com
Background Understanding health trends and estimating the burden of disease at the
national and subnational levels helps policy makers track progress and identify disparities in …
national and subnational levels helps policy makers track progress and identify disparities in …
Epidemiology of haemodialysis outcomes
Haemodialysis (HD) is the commonest form of kidney replacement therapy in the world,
accounting for approximately 69% of all kidney replacement therapy and 89% of all dialysis …
accounting for approximately 69% of all kidney replacement therapy and 89% of all dialysis …