Astrocytes are a population of cells with distinctive morphological and functional
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder
characterized by the progressive loss of neurons, which typically leads to severe …

Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

Background: Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory
drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been …

The beneficial actions of nonsteroidal anti‐inflammatory drugs (NSAIDs) have been linked to
their ability to inhibit inducible COX‐2 at sites of inflammation, and their side effects (eg …

Numerous epidemiologic studies have reported that the long-term use of nonsteroidal anti-
inflammatory drugs (NSAID) is associated with a significant decrease in cancer incidence …

An enzyme that can reduce methionine sulfoxide in proteins was first discovered in
Escherichia coli about 25 years ago. It is now apparent that there is a family of enzymes …

Alzheimer's disease (AD) is characterized by cerebral deposits of β‐amyloid (Aβ) peptides
and neurofibrillary tangles (NFT) which are surrounded by inflammatory cells …

Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription
factors that modulate target gene expression in response to endogenous and exogenous …

Abstract Overexpression of cyclooxygenase (COX)‐2 has been implicated in many
pathologic conditions, including cancer. One practical inference of this finding is that …