The tumor microenvironment innately modulates cancer progression

DC Hinshaw, LA Shevde - Cancer research, 2019 - AACR
Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …

Natural killer cells and other innate lymphoid cells in cancer

L Chiossone, PY Dumas, M Vienne… - Nature Reviews …, 2018 - nature.com
Immuno-oncology is an emerging field that has revolutionized cancer treatment. Most
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …

E-cadherin is required for metastasis in multiple models of breast cancer

V Padmanaban, I Krol, Y Suhail, BM Szczerba, N Aceto… - Nature, 2019 - nature.com
Metastasis is the major driver of death in patients with cancer. Invasion of surrounding
tissues and metastasis have been proposed to initiate following loss of the intercellular …

Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells

B Ruf, B Heinrich, TF Greten - Cellular & molecular immunology, 2021 - nature.com
Immune-based therapies such as immune checkpoint inhibitors have revolutionized the
systemic treatment of various cancer types. The therapeutic application of monoclonal …

The crosstalk between tumor cells and the immune microenvironment in breast cancer: implications for immunotherapy

V Salemme, G Centonze, F Cavallo, P Defilippi… - Frontiers in …, 2021 - frontiersin.org
Breast cancer progression is a complex process controlled by genetic and epigenetic factors
that coordinate the crosstalk between tumor cells and the components of tumor …

Innate immunity and cancer pathophysiology

L Maiorino, J Daßler-Plenker, L Sun… - Annual Review of …, 2022 - annualreviews.org
Chronic inflammation increases the risk of several cancers, including gastric, colon, and
hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory …

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

CSN Klose, D Artis - Nature immunology, 2016 - nature.com
Research over the last 7 years has led to the formal identification of innate lymphoid cells
(ILCs), increased the understanding of their tissue distribution and has established essential …

The ST2/IL-33 axis in immune cells during inflammatory diseases

B Griesenauer, S Paczesny - Frontiers in immunology, 2017 - frontiersin.org
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …

Contribution to tumor angiogenesis from innate immune cells within the tumor microenvironment: implications for immunotherapy

A Albini, A Bruno, DM Noonan, L Mortara - Frontiers in immunology, 2018 - frontiersin.org
The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …

IL-1 family members in cancer; two sides to every story

KJ Baker, A Houston, E Brint - Frontiers in immunology, 2019 - frontiersin.org
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …