The tumor microenvironment innately modulates cancer progression
DC Hinshaw, LA Shevde - Cancer research, 2019 - AACR
Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …
Natural killer cells and other innate lymphoid cells in cancer
L Chiossone, PY Dumas, M Vienne… - Nature Reviews …, 2018 - nature.com
Immuno-oncology is an emerging field that has revolutionized cancer treatment. Most
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …
E-cadherin is required for metastasis in multiple models of breast cancer
Metastasis is the major driver of death in patients with cancer. Invasion of surrounding
tissues and metastasis have been proposed to initiate following loss of the intercellular …
tissues and metastasis have been proposed to initiate following loss of the intercellular …
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells
Immune-based therapies such as immune checkpoint inhibitors have revolutionized the
systemic treatment of various cancer types. The therapeutic application of monoclonal …
systemic treatment of various cancer types. The therapeutic application of monoclonal …
[HTML][HTML] The crosstalk between tumor cells and the immune microenvironment in breast cancer: implications for immunotherapy
V Salemme, G Centonze, F Cavallo, P Defilippi… - Frontiers in …, 2021 - frontiersin.org
Breast cancer progression is a complex process controlled by genetic and epigenetic factors
that coordinate the crosstalk between tumor cells and the components of tumor …
that coordinate the crosstalk between tumor cells and the components of tumor …
Innate lymphoid cells and innate-like T cells in cancer—at the crossroads of innate and adaptive immunity
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …
many cancers, yet only a subset of patients benefit from these approaches. A better …
Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis
CSN Klose, D Artis - Nature immunology, 2016 - nature.com
Research over the last 7 years has led to the formal identification of innate lymphoid cells
(ILCs), increased the understanding of their tissue distribution and has established essential …
(ILCs), increased the understanding of their tissue distribution and has established essential …
[HTML][HTML] The ST2/IL-33 axis in immune cells during inflammatory diseases
B Griesenauer, S Paczesny - Frontiers in immunology, 2017 - frontiersin.org
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
[HTML][HTML] Contribution to tumor angiogenesis from innate immune cells within the tumor microenvironment: implications for immunotherapy
The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …
established. However, tumors show considerable variation in angiogenic characteristics and …
[HTML][HTML] IL-1 family members in cancer; two sides to every story
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …