Advances in the science and treatment of alcohol use disorder
K Witkiewitz, RZ Litten, L Leggio - Science advances, 2019 - science.org
Alcohol is a major contributor to global disease and a leading cause of preventable death,
causing approximately 88,000 deaths annually in the United States alone. Alcohol use …
causing approximately 88,000 deaths annually in the United States alone. Alcohol use …
Translational opportunities in animal and human models to study alcohol use disorder
Animal and human laboratory paradigms offer invaluable approaches to study the complex
etiologies and mechanisms of alcohol use disorder (AUD). We contend that human …
etiologies and mechanisms of alcohol use disorder (AUD). We contend that human …
[HTML][HTML] Overcoming the valley of death: a new model for high technology startups
SA Gbadegeshin, A Al Natsheh, K Ghafel… - Sustainable Futures, 2022 - Elsevier
Abstract The Valley of Death (VoD) reflects a series of challenges facing technology-based
companies during their early development stages. Extant literature highlights the need for …
companies during their early development stages. Extant literature highlights the need for …
Testing pharmacotherapies for alcohol use disorder with cue exposure paradigms: A systematic review and quantitative synthesis of human laboratory trial …
Alcohol cue exposure is a widely used experimental paradigm for screening
pharmacotherapies for alcohol use disorder (AUD). Medication‐related reductions in cue …
pharmacotherapies for alcohol use disorder (AUD). Medication‐related reductions in cue …
Alcohol and pain: a translational review of preclinical and clinical findings to inform future treatment strategies
Alcohol use disorder (AUD) and chronic pain are enduring and devastating conditions that
share an intersecting epidemiology and neurobiology. Chronic alcohol use itself can …
share an intersecting epidemiology and neurobiology. Chronic alcohol use itself can …
Alcohol-induced neuroinflammatory response and mitochondrial dysfunction on aging and Alzheimer's disease
Mitochondria are essential organelles central to various cellular functions such as energy
production, metabolic pathways, signaling transduction, lipid biogenesis, and apoptosis. In …
production, metabolic pathways, signaling transduction, lipid biogenesis, and apoptosis. In …
[HTML][HTML] Availability of medications for the treatment of alcohol and opioid use disorder in the USA
Despite high mortality rates due to opioid overdose and excessive alcohol consumption,
medications for the treatment of alcohol and opioid use disorder have not been widely used …
medications for the treatment of alcohol and opioid use disorder have not been widely used …
Applying the Addictions Neuroclinical Assessment to derive neurofunctional domains in individuals who use methamphetamine
Abstract The Addictions Neuroclinical Assessment (ANA) was proposed as a neuroscience-
informed clinical framework to understand heterogeneity in addiction encompassing …
informed clinical framework to understand heterogeneity in addiction encompassing …
A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized clinical trial
Rationale Screening novel medications for alcohol use disorder (AUD) requires models that
are both efficient and ecologically-valid. Ideally, such models would be associated with the …
are both efficient and ecologically-valid. Ideally, such models would be associated with the …
The future of translational research on alcohol use disorder
In March 2019, a scientific meeting was held at the University of California, Los Angeles
(UCLA) Luskin Center to discuss approaches to expedite the translation of neurobiological …
(UCLA) Luskin Center to discuss approaches to expedite the translation of neurobiological …