Activated JAK-STAT signaling is central to the pathogenesis of BCR-ABL-negative
myeloproliferative neoplasms (MPNs) and occurs as a result of MPN phenotypic driver …

To address the clinical relevance of small DNA variants in chronic myeloid neoplasms
(CMNs), an Association for Molecular Pathology Working Group comprehensively reviewed …

Acute myeloid leukemia (AML) is a complex, aggressive myeloid neoplasm characterized by
frequent somatic mutations that influence different functional categories' genes, resulting in …

Myeloid malignancy is a broad term encapsulating myeloproliferative neoplasms (MPN),
myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Initial studies into …

Platelets are key elements in thrombosis, particularly in atherosclerosis-associated arterial
thrombosis (atherothrombosis), and hemostasis. Megakaryocytes in the bone marrow …

Genomic instability, microenvironmental aberrations, and somatic mutations contribute to the
phenotype of myelodysplastic syndrome and the risk for transformation to AML. Genes …

Chronic myeloproliferative neoplasms (MPNs) are hematopoietic stem cell neoplasms with
driver events including the BCR-ABL1 translocation leading to a diagnosis of chronic …

Primary myelofibrosis (PMF), post-essential thrombocytemia and post-polycytemia vera
myelofibrosis (pET/pPV-MF) are potentially curable with allogeneic stem cell transplantation …

Isocitrate dehydrogenase (IDH) is a metabolic enzyme responsible for the enzymatic
conversion of isocitrate to α-ketoglutarate (α-KG). Mutations in the IDH gene result in a novel …

Owing to the introduction of next-generation sequencing (NGS) new challenges for
diagnostic algorithms and the interpretation of the results for therapeutic decision making in …