Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states
ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic …

The codependency of cholesterol metabolism sustains the malignant progression of
glioblastoma (GBM) and effective therapeutics remain scarce. In orthotopic GBM models in …

Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …

Inflammation is a hallmark of virtually all liver diseases, such as liver cancer, fibrosis,
nonalcoholic steatohepatitis, alcoholic liver disease, and cholangiopathies. Liver …

Tissue-resident macrophages are present in most tissues with developmental, self-renewal,
or functional attributes that do not easily fit into a textbook picture of a plastic and …

Age-related macular degeneration (AMD), a degenerative disease in the central macula
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …

The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly
investigated as a regulator of redox homeostasis. However, research over the past years …