The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed
loops through backsplicing. Recent methodologies have enabled in-depth characterization …

The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …

Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress
conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) …

The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate
and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is …

Technologies capable of programmable translation activation offer strategies to develop
therapeutics for diseases caused by insufficient gene expression. Here, we present …

In recent years, significant attention has focused on circular RNA (circRNA) translation to
determine its clinical significance. Cap-independent translation of circRNAs driven by an …

Viral myocarditis has been identified as a major cause of dilated cardiomyopathy (DCM) that
can lead to heart failure. Historically, Coxsackieviruses and adenoviruses have been …

MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than intrinsic regulatory capacity in mRNA translation. However, emerging studies reveal …