RNA-binding proteins in cancer: old players and new actors
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …
combination of versatility of their RNA-binding domains with structural flexibility enables …
[HTML][HTML] The multilayered complexity of ceRNA crosstalk and competition
Y Tay, J Rinn, PP Pandolfi - Nature, 2014 - nature.com
Recent reports have described an intricate interplay among diverse RNA species, including
protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs …
protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs …
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
M Sukumar, J Liu, Y Ji, M Subramanian… - The Journal of …, 2013 - Am Soc Clin Investig
Naive CD8+ T cells rely upon oxidation of fatty acids as a primary source of energy. After
antigen encounter, T cells shift to a glycolytic metabolism to sustain effector function. It is …
antigen encounter, T cells shift to a glycolytic metabolism to sustain effector function. It is …
LincRNA-p21 suppresses target mRNA translation
JH Yoon, K Abdelmohsen, S Srikantan, X Yang… - Molecular cell, 2012 - cell.com
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating
transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of …
transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of …
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
S Lebedeva, M Jens, K Theil, B Schwanhäusser… - Molecular cell, 2011 - cell.com
Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …
RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer
ABSTRACT RNA-binding proteins (RBPs) are key players in cellular physiology through
posttranscriptional regulation of the expression of target RNA transcripts. By modulating the …
posttranscriptional regulation of the expression of target RNA transcripts. By modulating the …
RNA-binding proteins in cancer: functional and therapeutic perspectives
D Kang, Y Lee, JS Lee - Cancers, 2020 - mdpi.com
Simple Summary RNA-binding proteins (RBPs) play central roles in regulating
posttranscriptional expression of genes. Many of them are known to be deregulated in a …
posttranscriptional expression of genes. Many of them are known to be deregulated in a …
The highways and byways of mRNA decay
NL Garneau, J Wilusz, CJ Wilusz - Nature reviews Molecular cell …, 2007 - nature.com
When considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …
MicroRNA regulation by RNA-binding proteins and its implications for cancer
M Van Kouwenhove, M Kedde, R Agami - Nature Reviews Cancer, 2011 - nature.com
Non-protein-coding transcripts have been conserved throughout evolution, indicating that
crucial functions exist for these RNAs. For example, microRNAs (miRNAs) have been found …
crucial functions exist for these RNAs. For example, microRNAs (miRNAs) have been found …
The role of the 3'untranslated region in post-transcriptional regulation of protein expression in mammalian cells.
E Matoulkova, E Michalova, B Vojtesek, R Hrstka - RNA biology, 2012 - Taylor & Francis
The untranslated regions (UTRs) at the 3'end of mRNA transcripts contain important
sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we …
sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we …