Background Diagnosing systemic juvenile idiopathic arthritis (SJIA) can be extremely
challenging if typical arthritis is lacking. A variety of biomarkers have been described for the …

Fibromyalgia is one of the numerous comorbidities that may accompany inflammatory
rheumatic diseases. Concomitant fibromyalgia in inflammatory rheumatic conditions can …

The CD40/CD40L axis plays a central role in the generation of humoral immune responses
and is an attractive target for treating autoimmune diseases in the clinic. Here, we report the …

Abstract Purpose Andecaliximab (GS-5745) is a highly selective monoclonal antibody
against matrix metalloproteinase-9 (MMP9), a proteolytic enzyme implicated in the …

Highlights•Many omics-based tests are proposed in the literature but very few make it to the
clinic.•First two multiplexed tests using selective reaction monitoring (SRM-MS) mass …

Synovial fluid (SF) is a protein-rich fluid produced into the joint cavity by cells of the synovial
membrane. Due to its direct contact with articular cartilage, surfaces of the bone, and the …

Dating to the discovery of the Lupus Erythematosus (LE) cell in 1948, there has been a
dramatic growth in the discovery of unique autoantibodies and their cognate targets, all of …

Immune dysregulation in systemic lupus erythematosus (SLE) contributes to increased
disease activity. African-American (AA) SLE patients have an increased prevalence of …

Background Musculoskeletal ultrasound (MSUS) and the multi-biomarker disease activity
(MBDA) score are outcome measures that may aid in the management of rheumatoid …

The objective of this study was to compare the effects of treatment by combined conventional
disease-modifying antirheumatic drugs (cDMARDs) or biologics on cytokines, disease …