Gut microbiota modulation of chemotherapy efficacy and toxicity

JL Alexander, ID Wilson, J Teare, JR Marchesi… - Nature reviews …, 2017 - nature.com
Evidence is growing that the gut microbiota modulates the host response to
chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; …

Effect of probiotics and gut microbiota on anti-cancer drugs: Mechanistic perspectives

A Badgeley, H Anwar, K Modi, P Murphy… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Bacteria present in probiotics, particularly the common Lactobacillus and Bifidobacterium
microbes, have been found to induce anti-cancer action by enhancing cancer cell apoptosis …

[HTML][HTML] Gut microbiota modulation of efficacy and toxicity of cancer chemotherapy and immunotherapy

D Chrysostomou, LA Roberts, JR Marchesi, JM Kinross - Gastroenterology, 2023 - Elsevier
Accumulating evidence supports not only the functional role of the gut microbiome in cancer
development and progression but also its role in defining the efficacy and toxicity of …

[HTML][HTML] Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer

SL Zhang, YQ Mao, ZY Zhang, ZM Li, CY Kong… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Anti-PD-1-based immunotherapy has emerged as a promising therapy for
several cancers. However, it only benefits a small subset of colorectal cancer (CRC) …

Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

M Sedighi, A Zahedi Bialvaei, MR Hamblin… - Cancer …, 2019 - Wiley Online Library
Successful treatment of cancer remains a challenge, due to the unique pathophysiology of
solid tumors, and the predictable emergence of resistance. Traditional methods for cancer …

Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies

C Panebianco, A Andriulli, V Pazienza - Microbiome, 2018 - Springer
Cancer is a major health burden worldwide, and despite continuous advances in medical
therapies, resistance to standard drugs and adverse effects still represent an important …

Systematic review: the role of the gut microbiota in chemotherapy‐or radiation‐induced gastrointestinal mucositis–current evidence and potential clinical applications

Y Touchefeu, E Montassier, K Nieman… - Alimentary …, 2014 - Wiley Online Library
Background Gastrointestinal mucositis is defined as inflammation and/or ulcers of the
gastrointestinal tract occurring as a complication of chemotherapy and radiation therapy …

Fecal microbiota transplantation prevents intestinal injury, upregulation of toll-like receptors, and 5-fluorouracil/oxaliplatin-induced toxicity in colorectal cancer

CW Chang, HC Lee, LH Li, JS Chiang Chiau… - International journal of …, 2020 - mdpi.com
FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin), a 5-fluorouracil (5-FU)-based
chemotherapy regimen, is one of most common therapeutic regimens for colorectal cancer …

[HTML][HTML] Chemotherapy-induced constipation and diarrhea: pathophysiology, current and emerging treatments

RM McQuade, V Stojanovska, R Abalo… - Frontiers in …, 2016 - frontiersin.org
Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked
clinical hurdle in cancer management. Chemotherapy-induced constipation (CIC) and …

[HTML][HTML] Probiotic mixture VSL# 3: An overview of basic and clinical studies in chronic diseases

FS Cheng, D Pan, B Chang, M Jiang… - World journal of clinical …, 2020 - ncbi.nlm.nih.gov
Probiotics are known as “live microorganisms” and have been proven to have a health effect
on hosts at the proper dose. Recently, a kind of probiotic mixture including eight live …