Sepsis: network pathophysiology and implications for early diagnosis

J Arora, AA Mendelson… - American Journal of …, 2023 - journals.physiology.org
Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …

The effect of sepsis on the erythrocyte

RM Bateman, MD Sharpe, M Singer… - International journal of …, 2017 - mdpi.com
Sepsis induces a wide range of effects on the red blood cell (RBC). Some of the effects
including altered metabolism and decreased 2, 3-bisphosphoglycerate are preventable with …

Impact of COVID‐19 on red blood cell rheology.

C Renoux, R Fort, E Nader, C Boisson… - British journal of …, 2021 - search.ebscohost.com
Abstract Keywords: COVID-19; red blood cell; deformability; aggregation; blood viscosity EN
COVID-19 red blood cell deformability aggregation blood viscosity e108 e111 4 02/17/21 …

Mechanisms of hemolysis during sepsis

K Effenberger-Neidnicht, M Hartmann - Inflammation, 2018 - Springer
Cell-free hemoglobin is increasingly playing a more central role in the pathogenesis of
sepsis being proved to be a potent predictor of patient's outcome. It is crucial, hence, to …

Red blood cell deformability, vasoactive mediators, and adhesion

TJ McMahon - Frontiers in physiology, 2019 - frontiersin.org
Healthy red blood cells (RBCs) deform readily in response to shear stress in the circulation,
facilitating their efficient passage through capillaries. RBCs also export vasoactive mediators …

[HTML][HTML] Molecular mechanisms of organ damage in sepsis: an overview

G Sygitowicz, D Sitkiewicz - Brazilian Journal of Infectious Diseases, 2021 - SciELO Brasil
Sepsis is one of the most common reasons for hospitalization. This condition is
characterized by systemic inflammatory response to infection. International definition of …

Microcirculatory dysfunction in sepsis: pathophysiology, clinical monitoring, and potential therapies

M Miranda, M Balarini, D Caixeta… - American Journal of …, 2016 - journals.physiology.org
Abnormal microvascular perfusion, including decreased functional capillary density and
increased blood flow heterogeneity, is observed in early stages of the systemic inflammatory …

Role and molecular mechanisms of pericytes in regulation of leukocyte diapedesis in inflamed tissues

P Rudziak, CG Ellis… - Mediators of inflammation, 2019 - Wiley Online Library
Leukocyte recruitment is a hallmark of the inflammatory response. Migrating leukocytes
breach the endothelium along with the vascular basement membrane and associated …

The conducted vasomotor response and the principles of electrical communication in resistance arteries

GY Mironova, PM Kowalewska… - Physiological …, 2024 - journals.physiology.org
Biological tissues are fed by arterial networks whose task is to set blood flow delivery in
accordance with energetic demand. Coordinating vasomotor activity among hundreds of …

August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data

DC Poole, RN Pittman, TI Musch… - The Journal of …, 2020 - Wiley Online Library
August Krogh twice won the prestigious international Steegen Prize, for nitrogen metabolism
(1906) and overturning the concept of active transport of gases across the pulmonary …